Evaluation of Toxic Side Effects of Clinically Used Skin Antiseptics In Vitro
HOCl Trust Introduction
This paper illustrates the potential benefit, but also the potential risks to tissues in the use of some widely used non-HOCl antiseptic products used on the skin. The study was studied in laboratory conditions, not on humans or other animals.
Source: Tobias Hirsch, M.D. et al Journal of Surgical Research, 1–7 (2009) doi:10.1016/j.jss.2009.04.029
Date: 2009
Abstract
This study compared five skin antiseptics to assess their effectiveness against bacteria and their toxicity to human skin cells in laboratory experiments. All five products showed antibacterial activity and some degree of toxicity, but their effects on skin cells varied. All five antiseptics showed towards human skin cells in laboratory tests. Lavasept and Prontosan combined strong antibacterial effectiveness with relatively low toxicity. Octenisept, Braunol and Betaisodona caused greater damage to skin cells and reduced their ability to grow. The findings highlight the importance of balancing infection control against potential harm to tissues needed for wound healing. The authors concluded that Lavasept and Prontosan offered the best overall balance of antibacterial effectiveness and cell safety.