Wait time after fogging with Hypochlorous Acid (HOCl)

This is not an exhaustive list, but a small, demonstrative referenced one highlighting the absence of the necessity to wait before occupying a space after fogging with HOCl.

Due to a compatible pH with human skin, and the fact that hypochlorous acid is made by the human immune system to fight pathogens and is non-cytotoxic, HOCl can be safely fogged in the presence of people ^1,9, topically applied to skin, is used for wound disinfection and accelerated healing ^2,8 as well as used for the treatment of eyelids ³ and as a nasal rinse ⁴,and a treatment for root canals, it is widely understood that HOCl is safe for exposure to humans when airborne.

“Topical stabilized HOCl provides an optimal wound healing environment and, when combined with silicone, may be ideal for reducing scarring. Additionally, in contrast to chlorhexidine, HOCl, used as an antiseptic skin preparation, raises no concerns of ocular-or ototoxicity.” ⁵

“We speculate that some ocular spray disinfectants that contain hypochlorous acid, usually applied to treat blepharitis in order to reduce bacterial and viral load on the skin and eye lashes, could be used as a measurement of prevention for the facial area where many other chemical agents cannot be applied.” ⁶

“HOCl has been incorporated into topical formulations due to antimicrobial, anti-inflammatory, immunomodulatory, and wound healing properties...Topical formulations of stabilized, pH-neutral HOCl (e.g., solution, gel, spray) have been evaluated in several studies demonstrating both antimicrobial effects and therapeutic benefit in many cutaneous disorders, including seborrheic dermatitis, atopic dermatitis-associated pruritus, acne vulgaris, diabetic foot ulcers, and hypertrophic scars/keloids. Topical HOCl appears to be well tolerated and safe, without any major adverse events reported.” ⁷

"Even the aerosolised form of BRIO HOCl, inhaled as a dense fog during area decontamination causes no adverse effects, and there are evaluations pending for therapeutic use as a nebulized topical laryngeal, tracheal, and alveolar disinfectant." ⁹

“...it may be stated that the occupants of the room considered that the slight irritation of the eyes, nose or throat, experienced by some of them (i.e. during Exp.19), was of no importance....It is concluded that the application of this method for air disinfection in crowded places such as air-raid shelters, some military quarters, and even in places of entertainment under epidemic conditions, would reduce the danger of the spread of infectious disease by transmission of air-borne bacteria.” ¹⁰

REFERENCES

1. Studies on Air-Borne Virus Infections in The Killing of Aerial Suspensions of Influenzavirus By Hypchlorous Acid By D. G. Ff. Edward And O. M. Lidwell, From the National Institute for Medical Research, London, N.W. https://www.cambridge.org/core/services/aop-cambridge-core/content /view/FED980BCC43BD8CD785AA70C05115496/S002217240001281Xa.pdf

2.  Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. Michael H. Gold MD, FAAD, Anneke Andriessen PhD, Ashish C. Bhatia MD, FAAD, Patrick Bitter Jr MD, FAAD, Suneel Chilukuri MD, FAAD, FACMS, Joel L. Cohen MD, FAAD, FACMS, Chris W. Robb MD, PhD.https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13280

3. The application of a saline hygiene solution preserved with pure HOCl acid reduced the bacterial load significantly without altering the diversity of bacterial species remaining on the skin under the lower eyelid. Clinical Ophthalmology 13_04_2017 David W Stroman, Keri Mintun, Arthur B Epstein, Crystal M Brimer, Chirag R Patel, James D Branch, Kathryn Najafi-Tagol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402722/pdf/opth-11-707.pdf 

4. Effects of a Low Concentration Hypochlorous Acid Nasal Irrigation Solution on Bacteria, Fungi, and Virus. The Laryngoscope02 January 2009 Hyun Jik Kim MD, Jeung‐Gweon Lee MD, Ju Wan Kang MD, Hyung‐Ju Cho MD, Hyun Su Kim MD, Hyung Kwon Byeon MD, Joo‐Heon Yoon MD https://onlinelibrary.wiley.com/doi/abs/10.1097/MLG.0b013e31817f4d34 

5. Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. Michael H. Gold MD, FAAD, Anneke Andriessen PhD, Ashish C. Bhatia MD, FAAD, Patrick Bitter Jr MD, FAAD, Suneel Chilukuri MD, FAAD, FACMS, Joel L. Cohen MD, FAAD, FACMS, Chris W. Robb MD, PhD. https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13280

6. COVID-19 Disease and Ophthalmology: An Update Received: April 28, 2020 .Mari ́a A. Amesty Jorge L. Alio ́ del Barrio Jorge L. Ali https://link.springer.com/content/pdf/10.1007/s40123-020-00260-y.pdf

7. Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modesof Action, and Study Outcomes by JAMES Q. DEL ROSSO, DO and NEAL BHATIA, MD. J Clin Aesthet Dermatol. 2018;11(11):36-39 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303114/

8. The Use of Hypochlorous Acid Lavage to Treat Infected Cavity Wounds . Wongkietkachorn, Apinut MD*; Surakunprapha, Palakorn MD†; Wittayapairoch, Jakrapan MD‡; Wongkietkachorn, Nuttapone MD§; Wongkietkachorn, Supawich MD Plastic and Reconstructive Surgery-Global Open: January 2020 -Volume 8 -Issue 1 -p e2604 https://journals.lww.com/prsgo/Fulltext/2020/01000/The_Use_of_Hypochlorous_Acid_Lavage_to_Treat.35.aspx

9. Stabilized hypochlorous acid disinfection for highly vulnerable populations: BRIO HOCL™ wound disinfection and area decontamination https://ieeexplore.ieee.org/document/8239259

10. Bacteriological observations on the air of occupied premises i. Air disinfection with hypochlorites. A simple practical method of disinfecting the air of occupied premises https://www.cambridge.org/core/journals/epidemiology-and-infection/article/bacteriological-observations-on-the-air-of-occupied-premises-i-air-disinfection-with-hypochlorites-a-simple-practical-method-of-disinfecting-the-air-of-occupied-premises/A625E1CE579CE5653CF8FF365C95E16D