Hypochlorous acid as a potential cavity conditioner for caries-affected dentin
HOCl Trust Introduction
A paper describing a very promising positive effect of HOCl that may be of significance for dental treatment procedures, as well as confirming microbiocidal effectivness.
Source
Sanon K, Elseoudy N, Hiraishi N, Tamura Y, Sanchavanakit N, ThanNaing S,
Shimada Y, Tagami J, Thongthai P. Hypochlorous acid as a potential cavity
conditioner for caries-affected dentin. Sci Rep. 2025 Jul 1;15(1):21438. doi:
10.1038/s41598-025-06191-7. PMID: 40596309; PMCID: PMC12217690.
Date: 2025
Abstract
This study looked at how HOCl affects tooth bonding, bacteria, and cell safety. Researchers used extracted human teeth with dental decay and treated some with a mild HOCl solution (50 ppm) before applying a dental adhesive. Untreated teeth were used as controls. They tested how well the filling material stuck to the affected dentin, how HOCl killed the bacteria Streptococcus mutans, and whether it was safe for dental pulp cells. Results showed that HOCl treatment made the bond to decayed dentin much stronger and more stable over time. HOCl also killed most of the bacteria and did not harm dental pulp cells, even at higher concentrations. These findings suggest that HOCl could be a useful dentin conditioner—helping fillings last longer, fighting bacteria, and remaining safe for living tissue.