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Mechanism of microbicidal action of E-101 solution, a myeloperoxidase-mediated antimicrobial, and its oxidative products

Source: Denys GA, Devoe NC, Gudis P, May M, Allen RC, Stephens JT, Jr. Infect Immun 87:e00261-1

Date: 2019


The antimicrobial effectiveness of hypochlorous acid, generated by a biochemical system treatment that utilises enzymes and substrates normally found within tissues, was examined in the presence of protein (horse serum) and human blood cells. The solution (E-101) demonstrated sustained and more potent killing than sodium oxychlorosene (a slow release agent for hypochlorous acid) against S. aureus in the presence of both serum and blood.

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